Eleanor Finch
Plasma is a watery liquid that makes up a little over half of the total volume of blood. It carries proteins and chemical compounds that are essential for the body to function. Plasma is also used in the medical field, where it can be donated and used to help others in a variety of ways. EMT subtype influences epithelial plasticity and mode of cell migration, and is associated with the re-localization of ECAD and other epithelial proteins to the interior of cancer cells. The main constitutes of plasma are water and proteins.
| Characteristics | Values |
|---|---|
| Main constitutes of plasma | Water and proteins |
| EMT subtype | P-EMT |
| P-EMT cell lines | PD7591, PD798 |
| C-EMT cell lines | PD483, PD3077 |
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What You'll Learn
- Plasma is a watery liquid that makes up over half of blood volume
- Plasma carries proteins and chemical compounds vital for the body
- It can be donated and used to help others in various ways
- Plasma disorders can be treated by plasmapheresis or plasma exchange
- EMTs must know the role of oxygen in the body and its relation to plasma
Plasma is a watery liquid that makes up over half of blood volume
Plasma is a colourless liquid that makes up a little over half of the total blood volume. It is a watery substance that carries blood cells and proteins to every corner of the body.
Plasma is made up of water and proteins. It also contains albumin, which helps maintain the balance between intracellular and extracellular fluid, preventing leakage into other tissues. Fibrinogen is another protein in plasma that helps the body form clots and repair tissues. Globulins are proteins that fight off infections and assist with blood clotting. Other proteins help the body defend itself, repair damage, and carry nutrients and vital compounds to other parts of the body.
The role of plasma is essential to the body's functioning. It allows blood to flow in a liquid form and carries proteins and chemical compounds that are vital for survival and for the body to function properly. Plasma can be donated and used to help others in various ways.
In the context of EMT, or epithelial-mesenchymal transition, plasma plays a role in cancer cell migration. EMT involves the re-localization of epithelial proteins within cancer cells, affecting their adhesion properties and motility. This process is influenced by the recycling of epithelial proteins and changes in gene expression.
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Plasma carries proteins and chemical compounds vital for the body
Plasma is the liquid component of blood, making up a little over half of its total volume. It is a pale, watery liquid that carries proteins and chemical compounds essential for the body's proper functioning.
One such protein is albumin, which helps maintain the balance between fluid inside the cells and plasma outside of them, preventing plasma leakage into other tissues. Fibrinogen is another protein found in plasma, which assists the body in forming clots and repairing tissues. Globulins are proteins that help fight off infections, transport substances in the bloodstream, and support blood clotting.
Other immune and transport proteins play a role in defending the body against infections, repairing damage, and carrying nutrients or vital compounds to different parts of the body. These proteins are crucial for maintaining health and ensuring the body's ability to respond to injuries and infections.
Additionally, plasma also contains platelets, which are involved in the clotting process and are crucial for preventing uncontrolled bleeding. The presence of these proteins and compounds in plasma underscores its vital role in maintaining the body's overall health and homeostasis.
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It can be donated and used to help others in various ways
Plasma is the liquid part of blood, making up a little over half of its total volume. It is a vital, pale, watery liquid that carries proteins and chemical compounds to keep the body functioning properly. It is composed mainly of water and proteins, with other blood cells such as red blood cells, white blood cells, and platelets mixing in with the plasma.
Plasma can be donated and used to help others in various ways. Donated plasma goes through a screening process and is then separated from other blood components. The leftover blood cells and platelets are returned to the donor's body. The donated plasma is then frozen to preserve clotting factors and immunoglobulins.
Donated plasma is used to treat a variety of conditions and diseases. For example, plasmapheresis or plasma exchange can be used to remove something from a patient's plasma or replace it entirely. Platelet-rich plasma injections can be used for certain injuries or diseases. Plasma donations can also be used for whole blood transfusions, where the plasma is separated in a laboratory as needed.
Additionally, plasma can be used to help others in the field of research. For instance, in the study of EMT (epithelial-mesenchymal transition), plasma plays a role in cancer cell migration and the loss of epithelial properties. Researchers have also successfully generated stable impermeable plasma, which has potential applications in the synthesis of nanostructures and the formation of complex nanomaterials.
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Plasma disorders can be treated by plasmapheresis or plasma exchange
Plasma is the liquid component of blood, making up a little over half of its total volume. It is a vital substance, carrying proteins and chemical compounds that are essential for keeping us alive and our bodies functioning properly. Plasma is composed mainly of water and proteins, with other electrolytes (dissolved salts) and immune and transport proteins also present.
Plasma exchange is used to treat disorders such as multiple sclerosis, myasthenia gravis, and Guillain-Barré syndrome, where antibodies attack the body's own tissues or nerves. It is also used to treat cryoglobulinemia, where proteins clump together and clog arteries, leading to inflammation and organ damage.
Possible complications from plasma exchange include hypocalcemia or hypomagnesemia, caused by the removal of calcium during the process, and hypothermia and hypotension due to low body temperature and blood pressure. However, these side effects can be treated with intravenous calcium, warm fluid infusion, and blood or plasma transfusions, respectively.
In addition to plasmapheresis and plasma exchange, other treatments for plasma disorders include platelet-rich plasma injections and whole blood donation, where plasma is separated and removed from the blood.
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EMTs must know the role of oxygen in the body and its relation to plasma
EMTs must have a good understanding of the role of oxygen in the body and its relation to plasma. Oxygen is vital for human survival, and it is transported in the blood in two forms.
Firstly, most oxygen in the blood is bound to haemoglobin, a metalloprotein with four subunits, each containing an iron atom that can bind to an oxygen molecule. This protein is contained within red blood cells, and each molecule of haemoglobin can carry four molecules of oxygen.
Secondly, a small amount of oxygen is physically dissolved in the plasma. Plasma is a colourless, watery liquid that makes up about 55% of the body's total blood volume. It is composed of up to 95% water and contains important dissolved proteins, glucose, clotting factors, electrolytes, hormones, and carbon dioxide.
Oxygen is poorly soluble in plasma, so only about 2% of oxygen is transported in this form. However, this percentage can increase when breathing 100% oxygen or during hyperbaric oxygenation. Henry's law states that the amount of oxygen dissolved in plasma is directly proportional to the partial pressure of oxygen.
The oxygen-carrying capacity of blood can be impaired by various defects in the synthesis or structure of red blood cells, haemoglobin, or the globin polypeptide chain, leading to a condition called hypoxia. EMTs should be aware of the signs and symptoms of hypoxia, which can result from impaired oxygen-carrying capacity, impaired unloading of oxygen from haemoglobin, or restricted blood supply.
Additionally, EMTs should understand the clinical measurements of oxygen in the blood, including partial pressure of dissolved oxygen, oxygen concentration, and haemoglobin saturation. These measurements are crucial in assessing the efficacy of oxygen transportation in the body and guiding medical interventions when necessary.
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Frequently asked questions
Water and proteins.
Plasma is a state of matter characterised by the presence of a significant portion of charged particles in any combination of ions or electrons.
Plasma carries proteins and chemical compounds that keep you alive and your body working properly.
P-EMT is associated with the re-localisation of ECAD and other epithelial proteins to the interior of the cancer cell.
ECAD is short for E-cadherin.
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